Relapsed Pulmonary Cryptococcosis during Tumor Necrosis Factor α Inhibitor Treatment

Clinical characteristics and treatment responses of patients who developed tuberculosis following use of a tumor necrosis factor-α inhibitor

BACKGROUND/AIMS Individuals being treated with tumor necrosis factor (TNF)-α inhibitors are at increased risk of developing tuberculosis (TB). We determined the clinical characteristics and treatment response of patients who developed TB after using TNF-α inhibitors. METHODS Patients with TB detected within 12 months of the initiation of TNF-α inhibitor treatment were included, if seen from J...

Possible pulmonary cryptococcosis in a patient with Crohn's disease during anti-tumor necrosis factor-alpha treatment: a case report and literature review.

Pulmonary and Peritoneal Tuberculosis Associated with Tumor Necrosis Factor-Alpha Inhibitor Use: A Case Report and Review of the Literature

The association between the use of tumor necrosis factor-α inhibitors and the increased risk of granulomatous infections, especially tuberculosis, has been well documented. Given the rapidly expanding list of inflammatory conditions for which tumor necrosis factor-α inhibitors are receiving FDA approval, the incidence of tuberculosis in this patient population has increased. Despite heightened ...

Effects of troxerutin on mRNA expression of the genes encoding lysozyme and tumor necrosis factor-α and histology in goldfish (Carassius auratus) skin

Troxerutin, a derivative of the natural bioflavonoid rutin, has important biological effects, including immunostimulatory activity. This study aimed to evaluate the effects of dietary troxerutin supplement on histology and mRNA expression of the genes encoding lysozyme and tumor necrosis factor-α in goldfish, Carassius auratus skin. Fish fingerlings with mean initial weights of 2.74 ± 0.08 g we...

Adjunctive TNF Inhibition with Standard Treatment Enhances Bacterial Clearance in a Murine Model of Necrotic TB Granulomas

BACKGROUND It has been hypothesized that early host-responses during TB treatment may paradoxically promote survival of persistent bacteria. We therefore evaluated whether adjunctive inhibition of tumor necrosis factor alpha (TNF-α)-a key cytokine in host responses against TB-could hasten bacterial clearance in a mouse strain that develops necrotic lesions in response to Mycobacterium tuberculo...